![]() They act on different parts of the cardiovascular system, mainly the heart and vascular resistances. Hypertonic saline dextran solution, as replacement fluid in isovolaemic haemodilution increased the magnitude of hypoxic pulmonary vasoconstriction, whereas dextran solution reduced it.įluid expanders are usually used for the resuscitation of intraoperative hypovolaemia or haemorragia. Dextran alone led to a decrease in mean PAP–LAP/Q values, and NaCl with dextran was associated with a significant shift of mean PAP–LAP/Q plots to higher pressures in hypoxia. kg −1) and after loading with sodium chloride (NaCl) 7.5% and dextran 6% or with dextran 6% alone.This enabled measurement of transpulmonary pressures (mean PAP minus LAP) at four levels of Q in hyperoxia (inspiratory oxygen fraction ( F i,O 2)=0.4), then in hypoxia ( F i,O 2=0.1) in the two groups before blood soustraction (10 mL ![]() A decrease in Q was obtained by reducing venous return. ![]() Mean pulmonary arterial pressure (PAP) and cardiac output (Q), systemic arterial pressure and left arterial pressure (LAP) were measured. The aim of the present study was to assess the extent to which hypertonic saline dextran and dextran solutions modify the magnitude of HPV during isovolumic haemodilution in intact acutely instrumented piglets.Įighteen large white piglets were anesthetised and assigned to two groups. ![]() Hypoxic pulmonary vasoconstriction (HPV) is a regulatory mechanism by which blood is diverted from poorly ventilated to better ventilated areas of the lung.
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